Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients.

@article{Guo2011InfusionOH,
  title={Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients.},
  author={Mei Guo and Kai-xun Hu and Chang-lin Yu and Qi-yun Sun and Jian-hui Qiao and Dan-hong Wang and Guang-xian Liu and Wan-jun Sun and Li Wei and Xue-dong Sun and Ya-jing Huang and Jun-xiao Qiao and Zheng Bang Dong and Hui-sheng Ai},
  journal={Blood},
  year={2011},
  volume={117 3},
  pages={936-41}
}
Treatment outcome of acute myeloid leukemia (AML) in elderly patients remains unsatisfactory. It has been shown that the infusion of granulocyte colony-stimulating factor-mobilized donor peripheral blood stem cells (G-PBSCs) can enhance graft-versus-leukemia effects and speed hematopoietic recovery. Fifty-eight AML patients aged 60-88 years were randomly assigned to receive induction chemotherapy with cytarabine and mitoxantrone (control group; n = 28) or it plus human leukocyte antigen… CONTINUE READING
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