Infusion of CCK-8 into hepatic-portal vein fails to reduce food intake in rats.

@article{Greenberg1987InfusionOC,
  title={Infusion of CCK-8 into hepatic-portal vein fails to reduce food intake in rats.},
  author={Danielle Greenberg and Gerard P Smith and James Gibbs},
  journal={The American journal of physiology},
  year={1987},
  volume={252 5 Pt 2},
  pages={R1015-8}
}
If the putative satiating effect of endogenous cholecystokinin (CCK) is produced through a circulating hormonal mechanism, then administration of exogenous CCK into the hepatic-portal vein should decrease meal size. To test this, one form of endogenous CCK, the C-terminal octapeptide CCK-8, was infused intraportally in doses of 4 and 8 micrograms/kg just prior to a test meal. Neither dose decreased food intake after intraportal infusion even though intraperitoneal administration of 4 micrograms… CONTINUE READING