Infrequent translation of a nonsense codon is sufficient to decrease mRNA level.

@article{Buzina1999InfrequentTO,
  title={Infrequent translation of a nonsense codon is sufficient to decrease mRNA level.},
  author={Alla Buzina and Marc J. Shulman},
  journal={Molecular biology of the cell},
  year={1999},
  volume={10 3},
  pages={
          515-24
        }
}
In many organisms nonsense mutations decrease the level of mRNA. In the case of mammalian cells, it is still controversial whether translation is required for this nonsense-mediated RNA decrease (NMD). Although previous analyzes have shown that conditions that impede translation termination at nonsense codons also prevent NMD, the residual level of termination was unknown in these experiments. Moreover, the conditions used to impede termination might also have interfered with NMD in other ways… CONTINUE READING

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