Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1

@article{Sun2004InfrequentMO,
  title={Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1},
  author={Chunlan Sun and Takashi Yamato and Emiko Kondo and Toru Furukawa and Hidetoshi Ikeda and Akira Horii},
  journal={Journal of Neuro-Oncology},
  year={2004},
  volume={73},
  pages={131-134}
}
We analyzed mutation of the APC, AXIN1, and GSK3genes in 14 pituitary adenomas with abnormal nuclear accumulations of CTNNB1. These tumors did not harbor mutation of the CTNNB1 gene. The genes analyzed encode proteins associated with ubiquitin-mediated degradation of CTNNB1. Although the regions encoding functional domains of these protein products were analyzed, no significant genetic alterations were found. Furthermore, the antibody for the C-terminus of APC detected normal expression of the… CONTINUE READING

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