Infrequent mutation in the BRCA2 gene in esophageal squamous cell carcinoma.

  title={Infrequent mutation in the BRCA2 gene in esophageal squamous cell carcinoma.},
  author={Nan Hu and Guang Li and Wen-Jun Li and Chaoyu Wang and Alisa M Goldstein and Ze-Zhong Tang and Mark J. Roth and Sanford M. Dawsey and Jing Huang and Quan-hong Wang and T P Ding and Carol A Giffen and Philip R. Taylor and Michael R. Emmert-Buck},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={8 4},
PURPOSE Previous studies have shown a high rate of allelic loss in esophageal squamous cell carcinoma (ESCC) in the vicinity of the BRCA2 gene. We aimed to assess whether the tumor suppressor gene BRCA2 was the inactivation target for allelic loss observed on chromosome 13q in ESCC. EXPERIMENTAL DESIGN We examined the entire coding sequence of the BRCA2 gene for mutations using single-strand conformation polymorphism analysis and DNA sequencing in 56 ESCC patients from Shanxi, China… CONTINUE READING


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Insight into the functions of BRCA1 and BRCA2

  • P. L. Welsch, K. N. Owens, M. C. King
  • Trends Genet.,
  • 2000
1 Excerpt

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