Infrequent Mutations in the PTEN/MMAC1 Gene among Primary Breast Cancers

@inproceedings{Ueda1998InfrequentMI,
  title={Infrequent Mutations in the PTEN/MMAC1 Gene among Primary Breast Cancers},
  author={Kazuki Ueda and Misae Nishijima and Hiroki Inui and Masahiro Watatani and Eiji Yayoi and Jun Okamura and Masayuki Yasutomi and Yusuke Nakamura and Yasuo Miyoshi},
  booktitle={Japanese journal of cancer research : Gann},
  year={1998}
}
Recently PTEN/MMAC1, a candidate tumor suppressor gene, was isolated from chromosome 10q23-24 and somatic mutations of this gene were detected in several malignancies including brain, prostate, and breast tumors. To investigate further the potential role of this gene in mammary carcinogenesis, we examined 69 primary breast cancers for mutations in PTEN/MMAC1 by means of polymerase chain reaction single-strand conformation polymorphism and sequencing analysis. We detected only one somatic… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 16 REFERENCES

PTEN / MMAC 1 Mutation in Breast Cancer 21 MMAC 1 gene in patients with Cowden disease

D. Liaw, D. J. Marsh, +8 authors C. Eng
  • 1997

carcinoma

A. Latil, J. C. Baron, +6 authors R. Lidereau
  • 1996