Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.

@article{Lei1996InfrequentDG,
  title={Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.},
  author={Junyi Lei and Tong Tong Zou and Yu Qian Shi and Xiao-ping Zhou and Kara N. Smolinski and J. -H. Yin and Rhonda F Souza and Rebecca Appel and Suna Wang and Karma Cymes and Olivia T Chan and John M. Abraham and Noam H Harpaz and Stephen J. Meltzer},
  journal={Oncogene},
  year={1996},
  volume={13 11},
  pages={2459-62}
}
Homozygously Deleted in Pancreatic Cancer 4 (DPC4), a recently identified candidate tumor suppressor gene, was previously shown to be altered in human pancreatic cancers. We examined DPC4 mutation in 30 examples of three other types of gastrointestinal malignancy: 10 esophageal cancers, 10 gastric cancers and 10 colorectal cancers occurring in the preneoplastic condition, ulcerative colitis. The entire coding region of DPC4 (including all 11 exons) was analysed by either direct sequencing of… CONTINUE READING

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