Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation

@inproceedings{Ruggeri2015InfraredNC,
  title={Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation},
  author={Francesco Simone Ruggeri and Giovanni Longo and Serena Faggiano and Ewelina Lipiec and Anna Pastore and Giovanni Dietler},
  booktitle={Nature communications},
  year={2015}
}
Amyloids are insoluble protein fibrillar aggregates. The importance of characterizing their aggregation has steadily increased because of their link to human diseases and material science applications. In particular, misfolding and aggregation of the Josephin domain of ataxin-3 is implicated in spinocerebellar ataxia-3. Infrared nanospectroscopy, simultaneously exploiting atomic force microscopy and infrared spectroscopy, can characterize at the nanoscale the conformational rearrangements of… CONTINUE READING

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