Inframolecular studies of the protonation of adenophostin A: comparison with 1-D-myo-inositol 1,4,5-trisphosphate.

@article{Felemez1999InframolecularSO,
  title={Inframolecular studies of the protonation of adenophostin A: comparison with 1-D-myo-inositol 1,4,5-trisphosphate.},
  author={M. Felemez and R. D. Marwood and B. Potter and B. Spiess},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={266 2},
  pages={
          334-40
        }
}
  • M. Felemez, R. D. Marwood, +1 author B. Spiess
  • Published 1999
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • Adenophostin A is a glyconucleotide natural product with the highest known potency for the D-myo-inositol 1,4,5-trisphosphate receptor. Using synthetic adenophostin A we have investigated the macroscopic and microscopic protonation process of this compound by performing (31)P NMR, (1)H NMR, and potentiometric titration experiments. The logarithms of the first to the fourth stepwise protonation constants are, respectively, log K(1) = 8.48, log K(2) = 6.20, log K(3) = 4.96, and log K(4) = 3.80… CONTINUE READING
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