Information transfer at the immunological synapse

  title={Information transfer at the immunological synapse},
  author={J{\'e}r{\^o}me Delon and Ronald N. Germain},
  journal={Current Biology},
Antigen-specific activation of T lymphocytes requires the interaction of their clonally distributed T-cell receptors with plasma membrane ligands composed of foreign peptide antigens bound to major histocompatibility complex molecules. For proliferation and differentiation to ensue, a variety of other adhesive and accessory proteins must also interact with their counter-receptors on the antigen-presenting cell to facilitate and complement the T-cell receptor-antigen recognition event. Recent… CONTINUE READING

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