Information transduction capacity of noisy biochemical signaling networks.

  title={Information transduction capacity of noisy biochemical signaling networks.},
  author={Raymond Cheong and Alex D Rhee and Chiaochun Joanne Wang and Ilya Nemenman and Andre Levchenko},
  volume={334 6054},
Molecular noise restricts the ability of an individual cell to resolve input signals of different strengths and gather information about the external environment. Transmitting information through complex signaling networks with redundancies can overcome this limitation. We developed an integrative theoretical and experimental framework, based on the formalism of information theory, to quantitatively predict and measure the amount of information transduced by molecular and cellular networks… CONTINUE READING
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