Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations.

@article{Rogan2003InformationTA,
  title={Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations.},
  author={Peter K. Rogan and Stan R Svojanovsky and J Steven Leeder},
  journal={Pharmacogenetics},
  year={2003},
  volume={13 4},
  pages={207-18}
}
Several mutations are known or suspected to affect mRNA splicing of CYP2C19, CYP2D6 and CYP3A5 genes; however, little experimental evidence exists to support these conclusions. The present study applies mathematical models that measure changes in information content of splice sites in these genes to demonstrate the relationship between the predicted phenotypes of these variants to the corresponding genotypes. Based on information analysis, the CYP2C19*2 variant activates a new cryptic site 40… CONTINUE READING

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