Information-theoretic analysis of phenotype changes in early stages of carcinogenesis.

  title={Information-theoretic analysis of phenotype changes in early stages of carcinogenesis.},
  author={Françoise Remacle and Nataly Kravchenko-Balasha and Alexander Levitzki and Raphael D. Levine},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 22},
Cancer is a multistep process characterized by altered signal transduction, cell growth, and metabolism. To identify such processes in early carcinogenesis we use an information theoretic approach to characterize gene expression quantified as mRNA levels in primary keratinocytes (K) and human papillomavirus 16 (HPV16)-transformed keratinocytes (HF1 cells) from early (E) and late (L) passages and from benzo(a)pyrene-treated (BP) L cells. Our starting point is that biological signaling processes… CONTINUE READING
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