Information Flow through a Model of the C. elegans Klinotaxis Circuit

@article{Izquierdo2015InformationFT,
  title={Information Flow through a Model of the C. elegans Klinotaxis Circuit},
  author={Eduardo J. Izquierdo and Paul L. Williams and Randall D. Beer},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
Understanding how information about external stimuli is transformed into behavior is one of the central goals of neuroscience. Here we characterize the information flow through a complete sensorimotor circuit: from stimulus, to sensory neurons, to interneurons, to motor neurons, to muscles, to motion. Specifically, we apply a recently developed framework for quantifying information flow to a previously published ensemble of models of salt klinotaxis in the nematode worm Caenorhabditis elegans… 
Neural model generating klinotaxis behavior accompanied by a random walk based on C. elegans connectome
TLDR
A connectome-based simulation model of C. elegans is presented to concurrently realize realistic klinotaxis and random walk behaviors and explore their neural mechanisms, providing a new hypothesis as to the neural mechanism underlying the random walk.
Decentralized Competition Produces Nonlinear Dynamics Akin to Klinotaxis
TLDR
This work presents a complex system model, in the form of a population of decentralized decision-making components (agents) whose aggregate activity resembles that observed in klinotaxis organisms, and reveals the complexity created by their collective feedback of information and actions akin to proportional navigation drives the model organism towards a specific target.
Persistent thermal input controls steering behavior in Caenorhabditis elegans
TLDR
It is found that, in all the evolved models, steering curvature are modulated by temporally persistent thermal signals sensed beyond the time scale of sinusoidal locomotion of C. elegans.
Persistent thermal input controls steering behavior in Caenorhabditis elegans
TLDR
This study indicates that C. elegans can steer toward a destination temperature without processing acute thermal input that informs to which direction it should steer.
A multilayer circuit architecture for the generation of distinct locomotor behaviors in Drosophila
TLDR
This work characterized Drosophila larval muscle activity patterns and premotor/motor circuits to understand how they generate forward and backward locomotion, and generated a recurrent network model that reproduced the observed behaviors.
A Drosophila larval premotor/motor neuron connectome generating two behaviors via distinct spatio-temporal muscle activity
TLDR
It is concluded that different locomotor behaviors can be generated by a specific group of premotor neurons generating behavior-specific motor rhythms.
Chemosensory signal transduction in Caenorhabditis elegans
TLDR
Current knowledge of the neurons, signal transduction molecules and regulatory mechanisms that underlie the response of C. elegans to chemicals, including pheromones are reviewed.
The Cognitive Lens: a primer on conceptual tools for analysing information processing in developmental and regenerative morphogenesis
TLDR
It is hypothesized that a cognitive-level information-processing view of the functions of living systems can complement reductive perspectives, improving efficient top-down control of organism-level outcomes and to understand biological patterning as a form of primitive cognition.
Models and mechanisms in network neuroscience
TLDR
An improved understanding is gained of the ways in which mathematical and computational models are deployed in network neuroscience, as well as an improved conception of mechanistic explanation in general.
...
1
2
...

References

SHOWING 1-10 OF 126 REFERENCES
Connecting a Connectome to Behavior: An Ensemble of Neuroanatomical Models of C. elegans Klinotaxis
TLDR
This paper develops a neuroanatomically-grounded model of salt klinotaxis, a form of chemotaxis in which changes in orientation are directed towards the source through gradual continual adjustments.
Evolution and Analysis of Minimal Neural Circuits for Klinotaxis in Caenorhabditis elegans
TLDR
A minimalistic neural network, comprised of an ON-OFF pair of chemosensory neurons and a pair of neck muscle motor neurons, is sufficient to generate realistic klinotaxis behavior, suggesting that the model may be operating according to principles similar to those of the biological network.
Circuit and Behavioral Analysis of Klinotaxis in Caenorhabditis elegans
TLDR
This dissertation investigates the neural basis of the sensorimotor transformation underlying a spatial orientation strategy in the nematode Caenorhabditis elegans and finds a minimal neuronal network for klinotaxis to sodium chloride including the ASE, AIY, AIZ, and SMB neuron classes that displays left/right asymmetry across the sensory neuron, interneuron, and motor neuron levels.
Structural Properties of the Caenorhabditis elegans Neuronal Network
TLDR
The wiring diagram reported here can help in understanding the mechanistic basis of behavior by generating predictions about future experiments involving genetic perturbations, laser ablations, or monitoring propagation of neuronal activity in response to stimulation.
Neural control of Caenorhabditis elegans forward locomotion: the role of sensory feedback
TLDR
A simple yet biologically-grounded model for the neural control of Caenorhabditis elegans forward locomotion finds that a minimal circuit of AVB interneurons and B-class motoneurons is sufficient to generate and sustain fictiveforward locomotion patterns that are robust to significant environmental perturbations.
Gait Modulation in C. elegans: An Integrated Neuromechanical Model
TLDR
A model of C. elegans forward locomotion is presented that includes a neuromuscular control system that relies on a sensory feedback mechanism to generate undulations and is integrated with a physical model of the body and environment and reproduces the entire swim-crawl transition with no modulatory mechanism.
Systems level circuit model of C. elegans undulatory locomotion: mathematical modeling and molecular genetics
TLDR
The model reveals that stretch receptor coupling in the body wall is critical for generation of the neuromuscular wave, and agrees with behavioral data and with other pertinent published data, e.g., that frequency is an increasing function of muscle gap-junction coupling.
Theory of the locomotion of nematodes: control of the somatic motor neurons by interneurons.
Neural Circuits Mediate Electrosensory Behavior in Caenorhabditis elegans
TLDR
Electrosensory behavior may be used as a model system for understanding how sensory inputs are transformed into motor outputs by the C. elegans nervous system.
Parallel Use of Two Behavioral Mechanisms for Chemotaxis in Caenorhabditis elegans
TLDR
Using laser ablation of individual neurons to examine the underlying neural circuit, it is found the ASE sensory neurons and AIZ interneurons are essential for both the pirouette and weathervane mechanisms in chemotaxis to NaCl.
...
1
2
3
4
5
...