Informatics and multiplexing of intact protein identification in bacteria and the archaea

@article{Meng2001InformaticsAM,
  title={Informatics and multiplexing of intact protein identification in bacteria and the archaea},
  author={Fanyu Meng and Benjamin J. Cargile and Leah M. Miller and Andrew J. Forbes and Jeremy R. Johnson and Neil L. Kelleher},
  journal={Nature Biotechnology},
  year={2001},
  volume={19},
  pages={952-957}
}
Although direct fragmentation of protein ions in a mass spectrometer is far more efficient than exhaustive mapping of 1–3 kDa peptides for complete characterization of primary structures predicted from sequenced genomes, the development of this approach is still in its infancy. Here we describe a statistical model (good to within ∼5%) that shows that the database search specificity of this method requires only three of four fragment ions to match (at ±0.1 Da) for a 99.8% probability of being… CONTINUE READING

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