Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts

@article{Pitman2019InfluxRO,
  title={Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts},
  author={Kathinka E Pitman and Santosh Reddy Alluri and Alexandr Kristian and Eva Katrine Aarnes and Heidi Lyng and Patrick Johannes Riss and Eirik Malinen},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2019},
  pages={1-9}
}
Purpose18F-fluoroaminosuberic acid (18F-FASu) is a recently developed amino acid tracer for positron emission tomography (PET) of oxidative stress that may offer improved tumour assessment over the conventional tracer 18F-fluorodeoxyglucose (18F-FDG). Our aim was to evaluate and relate dynamic 18F-FASu and 18F-FDG uptake with pharmacokinetic modelling to transporter protein expression levels in a panel of diverse tumour xenograft lines.MethodsFour different tumour xenograft lines were implanted… 

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