Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts

  title={Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts},
  author={Kathinka E Pitman and Santosh Reddy Alluri and Alexandr Kristian and Eva Katrine Aarnes and Heidi Lyng and Patrick Johannes Riss and Eirik Malinen},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
Purpose18F-fluoroaminosuberic acid (18F-FASu) is a recently developed amino acid tracer for positron emission tomography (PET) of oxidative stress that may offer improved tumour assessment over the conventional tracer 18F-fluorodeoxyglucose (18F-FDG). Our aim was to evaluate and relate dynamic 18F-FASu and 18F-FDG uptake with pharmacokinetic modelling to transporter protein expression levels in a panel of diverse tumour xenograft lines.MethodsFour different tumour xenograft lines were implanted… 

Figures and Tables from this paper

Synthesis, radiosynthesis and positron emission tomography neuroimaging using 5-[18 F]fluoro-L-amino suberate.
The synthesis procedures of tosylate precursor and its translation to Sxc - PET tracer 5[18F]fluoro-L-amino suberate by manual and automated radiosyntheses are described and a brain-PET study has been conducted to evaluate the tracer uptake into brain in healthy mice.
SLC7A11/xCT in cancer: biological functions and therapeutic implications.
This review summarizes current available data of how SLC7A11 is subjected to fine regulations at multiple levels and proposes novel insights for future perspectives on the modulation of SLC 7A11, as well as possible targeted strategies for SLC6A11-based anti-cancer therapies.
Ferroptosis: The Silver Lining of Cancer Therapy
The characteristics of ferroptotic cells, associated mechanisms offerroptosis occurrence and regulation and application of the ferroPTotic pathway in cancer therapy, including the use of ferraptosis in combination with other therapeutic modalities are summarised.
Integrating metabolic reprogramming and metabolic imaging to predict breast cancer therapeutic responses


Positron emission tomography and pharmacokinetics of 2-[18F]-fluoroethyl choline for metabolic studies in breast cancer xenografts
Abstract Background. Breast carcinomas (BC) can have abnormal choline (Cho) metabolism. Earlier studies indicated that Cho uptake can differ between different subtypes of BC. The purpose of this
(4S)-4-(3-18F-Fluoropropyl)-l-Glutamate for Imaging of xC¯ Transporter Activity in Hepatocellular Carcinoma Using PET: Preclinical and Exploratory Clinical Studies
Strong tumor uptake and low background from nontarget tissue allowed excellent tumor visualization in animal models with orthotopically implanted liver tumors and 18F-FSPG may be a promising tumor PET agent with a high cancer detection rate in patients with HCC.
Variability of dynamic 18F-FDG-PET data in breast cancer xenografts
The pharmacokinetic tumour metrics again display much greater variability than the SUV-based metrics, however, it is generally not known which of these metrics that best represents cancer aggressiveness and their use may still depend on the research questions addressed.
Functional Imaging of Oxidative Stress with a Novel PET Imaging Agent, 18F-5-Fluoro-l-Aminosuberic Acid
The synthesis and in vitro and in vivo validation of a lead candidate, 18F-5-fluoro-aminosuberic acid (18F-FASu), as a PET tracer for functional imaging of a cellular response to oxidative stress with remarkable tumor uptake and retention are reported.
Cilengitide affects tumor compartment, vascularization and microenvironment in experimental bone metastases as shown by longitudinal 18F-FDG PET and gene expression analysis
Gene expression analysis from bone metastases revealed that tumor-produced integrins (αvβ5) as well as factors relevant for angiogenesis, bone resorption, extracellular matrix remodeling and bone marrow microenvironment were significantly reduced upon therapy with cilengitide.
Dynamic 18 F-FDG PET for Assessment of Tumor Physiology in Two Breast Carcinoma Xenografts
Significant differences in dynamic 18 F-FDG parameters between the two human breast cancer xenografts were found and could be explained by underlying histological and physiological characteristics.
Monitoring primary breast cancer throughout chemotherapy using FDG-PET
FDG-PET is efficacious for predicting the pathologic response of most primary breast tumours throughout the duration of a neoadjuvant chemotherapy regimen, however, this technique is ineffective for tumours with low image contrast on pre-therapy PET scans.
Kinetic Evaluation of [11C]Dihydrotetrabenazine by Dynamic PET: Measurement of Vesicular Monoamine Transporter
  • R. Koeppe, K. Frey, D. Kuhl
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1996
It is concluded that (+)-α-[11C]DTBZ and PET can provide excellent measures of VMAT2 density in the human brain.
Preclinical dynamic 18F-FDG PET – tumor characterization and radiotherapy response assessment by kinetic compartment analysis
The feasibility of a two-tissue compartment kinetic analysis of dynamic 18F-FDG PET images is demonstrated, and extracted parametrical maps might contribute to tumor biological characterization and radiotherapy response assessment.