Influx of extracellular calcium regulates actin-dependent morphological plasticity in dendritic spines.

@article{Brnig2004InfluxOE,
  title={Influx of extracellular calcium regulates actin-dependent morphological plasticity in dendritic spines.},
  author={Ina Br{\"u}nig and Stefanie Kaech and Heike Brinkhaus and Thomas G. Oertner and Andrew Matus},
  journal={Neuropharmacology},
  year={2004},
  volume={47 5},
  pages={669-76}
}
Dendritic spines contain a specialized cytoskeleton composed of dynamic actin filaments capable of producing rapid changes in their motility and morphology. Transient changes in Ca2+ levels in the spine cytoplasm have been associated with the modulation of these effects in a variety of ways. To characterize the contribution of Ca2+ fluxes originating through different pathways to these phenomena, we used time-lapse imaging of cultured hippocampal neurons expressing GFP-actin to follow the… CONTINUE READING
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