Influenza virus polymerase basic protein 1 interacts with influenza virus polymerase basic protein 2 at multiple sites.

@article{Biswas1996InfluenzaVP,
  title={Influenza virus polymerase basic protein 1 interacts with influenza virus polymerase basic protein 2 at multiple sites.},
  author={Siddhartha K. Biswas and Debi Prosad Nayak},
  journal={Journal of virology},
  year={1996},
  volume={70 10},
  pages={
          6716-22
        }
}
Three polymerase proteins of influenza type A virus interact with each other to form the active polymerase complex. Polymerase basic protein 1 (PB1) can interact with PB2 in the presence or absence of polymerase acidic protein. In this study, we investigated the domains of PB1 involved in complex formation with PB2 in vivo, using coexpression and coimmunoprecipitation of the PB1-PB2 complex with monospecific antibodies. Results show that PB1 possesses at least two regions which can interact… CONTINUE READING

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