Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options

@inproceedings{Kido2015InfluenzaVP,
  title={Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options},
  author={Hiroshi Kido},
  booktitle={Proceedings of the Japan Academy. Series B, Physical and biological sciences},
  year={2015}
}
Influenza A virus (IAV) causes significant morbidity and mortality. The knowledge gained within the last decade on the pandemic IAV(H1N1)2009 improved our understanding not only of the viral pathogenicity but also the host cellular factors involved in the pathogenicity of multiorgan failure (MOF), such as cellular trypsin-type hemagglutinin (HA0) processing proteases for viral multiplication, cytokine storm, metabolic disorders and energy crisis. The HA processing proteases in the airway and… CONTINUE READING
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