Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors.

@article{Zhu2012InfluenzaVN,
  title={Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors.},
  author={Xueyong Zhu and Ryan McBride and Corwin M. Nycholat and Wenli Yu and James C Paulson and Ian A. Wilson},
  journal={Journal of virology},
  year={2012},
  volume={86 24},
  pages={13371-83}
}
Influenza virus neuraminidase (NA) cleaves off sialic acid from cellular receptors of hemagglutinin (HA) to enable progeny escape from infected cells. However, NA variants (D151G) of recent human H3N2 viruses have also been reported to bind receptors on red blood cells, but the nature of these receptors and the effect of the mutation on NA activity were not established. Here, we compare the functional and structural properties of a human H3N2 NA from A/Tanzania/205/2010 and its D151G mutant… CONTINUE READING
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