Influenza virus-membrane fusion triggered by proton uncaging for single particle studies of fusion kinetics.

@article{Costello2012InfluenzaVF,
  title={Influenza virus-membrane fusion triggered by proton uncaging for single particle studies of fusion kinetics.},
  author={Deirdre A. Costello and Donald W. Lee and Jennifer E Drewes and Kevin A Vasquez and Kassandra Kisler and Ulrich B Wiesner and Lois Pollack and Gary R. Whittaker and Susan Daniel},
  journal={Analytical chemistry},
  year={2012},
  volume={84 20},
  pages={8480-9}
}
We report a method for studying membrane fusion, focusing on influenza virus fusion to lipid bilayers, which provides high temporal resolution through the rapid and coordinated initiation of individual virus fusion events. Each fusion event proceeds through a series of steps, much like multistep chemical reaction. Fusion is initiated by a rapid decrease in pH that accompanies the "uncaging" of an effector molecule from o-nitrobenzaldehyde, a photoisomerizable compound that releases a proton to… CONTINUE READING
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The Handbook: A Guide to Fluorescent Probes and Labeleing Technologies

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