Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation?

@article{Burgui2007InfluenzaVM,
  title={Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation?},
  author={Idoia Burgui and Emilio Y{\'a}ng{\"u}ez and Nahum Sonenberg and Alberto Nieto},
  journal={Journal of virology},
  year={2007},
  volume={81 22},
  pages={
          12427-38
        }
}
Influenza virus mRNAs bear a short capped oligonucleotide sequence at their 5' ends derived from the host cell pre-mRNAs by a "cap-snatching" mechanism, followed immediately by a common viral sequence. At their 3' ends, they contain a poly(A) tail. Although cellular and viral mRNAs are structurally similar, influenza virus promotes the selective translation of its mRNAs despite the inhibition of host cell protein synthesis. The viral polymerase performs the cap snatching and binds selectively… CONTINUE READING

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