Influenza virus inhibits RNA polymerase II elongation.

@article{Chan2006InfluenzaVI,
  title={Influenza virus inhibits RNA polymerase II elongation.},
  author={Annie Shuk Yee Chan and Frank Theodoor Vreede and Matt Smith and Othmar G Engelhardt and Ervin Fodor},
  journal={Virology},
  year={2006},
  volume={351 1},
  pages={
          210-7
        }
}
The influenza virus RNA-dependent RNA polymerase interacts with the serine-5 phosphorylated carboxy-terminal domain (CTD) of the large subunit of RNA polymerase II (Pol II). It was proposed that this interaction allows the viral RNA polymerase to gain access to host mRNA-derived capped RNA fragments required as primers for the initiation of viral mRNA synthesis. Here, we show, using a chromatin immunoprecipitation (ChIP) analysis, that similar amounts of Pol II associate with Pol II promoter… CONTINUE READING
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