Influenza virus infection increases p53 activity: role of p53 in cell death and viral replication.

@article{Turpin2005InfluenzaVI,
  title={Influenza virus infection increases p53 activity: role of p53 in cell death and viral replication.},
  author={Elizabeth Turpin and Kimberly Luke and Jeremy O Jones and Terrence M. Tumpey and Kouacou Konan and Stacey T Schultz-Cherry},
  journal={Journal of virology},
  year={2005},
  volume={79 14},
  pages={8802-11}
}
The induction of apoptotic cell death is a hallmark of influenza virus infection. Although a variety of cellular and viral proteins have been implicated in this process, to date no conserved cellular pathway has been identified. In this study, we report that the tumor suppressor protein p53 is essential for the induction of cell death in influenza virus-infected cells. In primary human lung cells, influenza virus increased p53 protein levels. This was also noted in the human lung cell line A549… CONTINUE READING