Influenza virus-induced NF-kappaB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase.

@article{Flory2000InfluenzaVN,
  title={Influenza virus-induced NF-kappaB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase.},
  author={Egbert Flory and Manfred Kunz and Carsten Scheller and Christian Jassoy and Roland Stauber and Ulf R{\"u}diger Rapp and Stephan Ludwig},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 12},
  pages={8307-14}
}
Influenza A viruses are capable of inducing the expression of a variety of cytokine and proapoptotic genes in infected cells. The promoter regions of most of these genes harbor binding sites for the transcription factor NF-kappaB which is an important mediator of immune and inflammatory responses. Our present study is based on an observation that influenza… CONTINUE READING