Influenza virus RNA replication in vitro: synthesis of viral template RNAs and virion RNAs in the absence of an added primer.

@article{Shapiro1988InfluenzaVR,
  title={Influenza virus RNA replication in vitro: synthesis of viral template RNAs and virion RNAs in the absence of an added primer.},
  author={Geoffrey I. Shapiro and Robert Krug},
  journal={Journal of virology},
  year={1988},
  volume={62 7},
  pages={2285-90}
}
The two steps in influenza virus RNA replication are (i) the synthesis of template RNAs, i.e., full-length copies of the virion RNAs, and (ii) the copying of these template RNAs into new virion RNAs. We prepared nuclear extracts from infected HeLa cells that catalyzed both template RNA and virion RNA synthesis in vitro in the absence of an added primer. Antibody depletion experiments implicated nucleocapsid protein molecules not associated with nucleocapsids in template RNA synthesis for… CONTINUE READING

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Vesicular stomatitis virus proteins required for the in vitro replication of defective interfering particle genome RNA, p. 153-160

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  • 1984
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