Influenza virus ISCOMs: antibody response in animals.

@article{Sundquist1988InfluenzaVI,
  title={Influenza virus ISCOMs: antibody response in animals.},
  author={B G Sundquist and Kurt Ingmar Loevgren and Bror Morein},
  journal={Vaccine},
  year={1988},
  volume={6 1},
  pages={
          49-53
        }
}
A monovalent experimental ISCOM vaccine has been prepared with the envelope glycoproteins haemagglutinin and neuraminidase of the equine virus strain A/Solvalla/79 (H3N8). In vaccination trials on BALB/c mice the ISCOM vaccine induced more than ten times higher serum antibody titres measured in ELISA than a corresponding experimental micelle vaccine. Similarly, in guinea-pigs the ISCOMs induced about tenfold higher haemagglutination inhibition (HI) and neuraminidase inhibition (NI) titres than… CONTINUE READING

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