Influenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge.

@article{Haynes2009InfluenzapseudotypedGV,
  title={Influenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge.},
  author={Joel R. Haynes and Leslie Dokken and James A. Wiley and Andrew G. Cawthon and John E. Bigger and Allen G. Harmsen and Charles Richardson},
  journal={Vaccine},
  year={2009},
  volume={27 4},
  pages={530-41}
}
Influenza-pseudotyped Gag virus-like particles (VLPs) were produced via the expression of influenza hemagglutinin (HA), neuraminidase (NA) and the murine leukemia virus Gag product in the baculovirus-insect cell expression system. Hemagglutination specific activities of sucrose gradient-purified VLPs were similar to those of egg-grown influenza viruses but particle morphologies were gamma retrovirus-like in the form of consistent 100nm spheres. Immunization of mice and ferrets demonstrated… CONTINUE READING