Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source.

@article{Siegel2014InfluenzaPP,
  title={Influenza promotes pneumococcal growth during coinfection by providing host sialylated substrates as a nutrient source.},
  author={Steven J. Siegel and Aoife M. Roche and Jeffrey N Weiser},
  journal={Cell host & microbe},
  year={2014},
  volume={16 1},
  pages={55-67}
}
Much of the mortality attributed to influenza virus is due to secondary bacterial pneumonia, particularly from Streptococcus pneumoniae. However, mechanisms underlying this coinfection are incompletely understood. We find that prior influenza infection enhances pneumococcal colonization of the murine nasopharynx, which in turn promotes bacterial spread to the lungs. Influenza accelerates bacterial replication in vivo, and sialic acid, a major component of airway glycoconjugates, is identified… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 19 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 55 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Insights into the interaction between influenza virus and pneumococcus.

Clinical microbiology reviews • 2006
View 7 Excerpts
Highly Influenced

Immune dysfunction and bacterial coinfections following influenza.

Journal of immunology • 2013
View 6 Excerpts
Highly Influenced

The role of influenza and parainfluenza infections in nasopharyngeal pneumococcal acquisition among young children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2014

Similar Papers

Loading similar papers…