Influenza hemagglutinin membrane anchor

@inproceedings{Benton2018InfluenzaHM,
  title={Influenza hemagglutinin membrane anchor},
  author={Donald J Benton and Andrea Nans and Lesley J. Calder and Jack Turner and Ursula Neu and Yi Pu Lin and Esther Ketelaars and Nicole L Kallewaard and Davide Corti and Antonio Lanzavecchia and Steven J. Gamblin and Peter B Rosenthal and John J. Skehel},
  booktitle={Proceedings of the National Academy of Sciences of the United States of America},
  year={2018}
}
Viruses with membranes fuse them with cellular membranes, to transfer their genomes into cells at the beginning of infection. For Influenza virus, the membrane glycoprotein involved in fusion is the hemagglutinin (HA), the 3D structure of which is known from X-ray crystallographic studies. The soluble ectodomain fragments used in these studies lacked the "membrane anchor" portion of the molecule. Since this region has a role in membrane fusion, we have determined its structure by analyzing the… CONTINUE READING
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