Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination.

@article{Zhang2016InfluenzabindingSP,
  title={Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination.},
  author={Zhiyue Zhang and Bert Schepens and Lutz Nuhn and Xavier Saelens and Michael Schotsaert and Nico 3 Callewaert and Riet De Rycke and Qilu Zhang and Seb́astien Moins and Samira Benali and Laetitia Mespouille and Richard Hoogenboom and Bruno G De Geest},
  journal={Chemical communications},
  year={2016},
  volume={52 16},
  pages={3352-5}
}
We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol-gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-α-2-6-Gal, and we demonstrate… CONTINUE READING