Influenza Pathogenesis and Control - Volume I

  title={Influenza Pathogenesis and Control - Volume I},
  author={Richard W. Compans and Michael B A Oldstone and Rafi Ahmed},
  booktitle={Current Topics in Microbiology and Immunology},
The hemagglutinin (HA) is a prime determinant of the pathogenicity of influenza A viruses. It initiates infection by binding to cell surface receptors and by inducing membrane fusion. The fusion capacity of HA depends on cleavage activation by host proteases, and it has long been known that highly pathogenic avian influenza viruses displaying a multibasic… CONTINUE READING