Influenza-Induced Production of Interferon-Alpha is Defective in Geriatric Individuals

  title={Influenza-Induced Production of Interferon-Alpha is Defective in Geriatric Individuals},
  author={David H Canaday and Naa Ayele Amponsah and Leola Jones and Daniel J. Tisch and Thomas R. Hornick and Lakshmi Ramachandra},
  journal={Journal of Clinical Immunology},
The majority of deaths (90%) attributed to influenza are in person’s age 65 or older. Little is known about whether defects in innate immune responses in geriatric individuals contribute to their susceptibility to influenza. Our aim was to analyze interferon-alpha (IFN-alpha) production in peripheral blood mononuclear cells (PBMCs) isolated from young and geriatric adult donors, stimulated with influenza A or Toll-like receptor (TLR) ligands. IFN-alpha is a signature anti-viral cytokine that… CONTINUE READING
16 Citations
77 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 16 extracted citations


Publications referenced by this paper.
Showing 1-10 of 77 references

Similar Papers

Loading similar papers…