Influenza A virus infection of macrophages. Enhanced tumor necrosis factor-alpha (TNF-alpha) gene expression and lipopolysaccharide-triggered TNF-alpha release.

@article{Gong1991InfluenzaAV,
  title={Influenza A virus infection of macrophages. Enhanced tumor necrosis factor-alpha (TNF-alpha) gene expression and lipopolysaccharide-triggered TNF-alpha release.},
  author={Jinmei Gong and Hans Sprenger and F Hinder and Ariane Bender and Andrea B. Schmidt and S Horch and Marianne Nain and Diethard Gemsa},
  journal={Journal of immunology},
  year={1991},
  volume={147 10},
  pages={3507-13}
}
We have previously shown that infection of macrophages by influenza A virus is capable of priming for a high TNF-alpha production in response to LPS. The present study was designed to examine in more detail TNF-alpha gene expression and TNF-alpha protein release of virus-infected, murine PU5-1.8 macrophages in the presence or absence of low and by itself rather inefficient concentrations of LPS (10 ng/ml). Although influenza A virus infection alone induced a massive TNF-alpha mRNA accumulation… CONTINUE READING
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