Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase

@inproceedings{Cohen2013InfluenzaAP,
  title={Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase},
  author={Miriam Cohen and Xing-quan Zhang and Hooman P. Senaati and Hui-Wen Chen and Nissi M. Varki and Robert Turner Schooley and Pascal Gagneux},
  booktitle={Virology Journal},
  year={2013}
}
Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans. Inhibiting NA with oseltamivir suppresses both viral infection, and viral release from cultured human airway epithelial cells. The role of NA in viral exit is well established: it releases budding virions by cleaving Sias from glycoconjugates on infected cells and progeny virions. The role of NA in viral entry remains unclear. Host respiratory epithelia secrete a mucus layer rich in heavily sialylated… CONTINUE READING
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