Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.

@article{Barbier2012InfluenzaAI,
  title={Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.},
  author={Diane Barbier and Ignacio Garcia-Verdugo and Julien Pothlichet and Roxana Khazen and Delphyne Descamps and Karine Rousseau and David N. Thornton and Mustapha Si-Tahar and Lhousseine Touqui and Michel Chignard and Jean-Michel Sallenave},
  journal={American journal of respiratory cell and molecular biology},
  year={2012},
  volume={47 2},
  pages={
          149-57
        }
}
Mucins, the main glycoproteins present within mucus, modulate the rheologic properties of airways and participate in lung defense. They are thought to be able to trap and eliminate microorganisms from the lung. Among the mucins secreted in the lung, MUC5AC is the most prominent factor secreted by surface epithelial cells. Although much is known about the signaling pathways involved in the regulation of MUC5AC by host factors such as cytokines or proteases, less is known about the pathways… CONTINUE READING
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