Influenza A and sendai viruses induce differential chemokine gene expression and transcription factor activation in human macrophages.

@article{Matikainen2000InfluenzaAA,
  title={Influenza A and sendai viruses induce differential chemokine gene expression and transcription factor activation in human macrophages.},
  author={Sampsa Matikainen and Jaana Pirhonen and Minja Miettinen and Anne Lehtonen and C Govenius-Vintola and Timo Sareneva and Ilkka Julkunen},
  journal={Virology},
  year={2000},
  volume={276 1},
  pages={138-47}
}
Chemokines regulate leukocyte traffic and extravasation into the site of inflammation. Here we show that influenza A- or Sendai virus-infected human macrophages produce MIP-1alpha, MIP-1beta, RANTES, MCP-1, MCP-3, MIP-3alpha, IP-10, and IL-8, whereas no upregulation of MIP-3beta, eotaxin, or MDC production was detected. Influenza A virus was a better inducer of MCP-1 and MCP-3 production than Sendai virus, whereas MIP-1alpha, MIP-1beta, RANTES, MIP-3alpha, and IL-8 were induced preferentially… CONTINUE READING