Influenza A Virus Infection of Human Primary Dendritic Cells Impairs Their Ability to Cross-Present Antigen to CD8 T Cells

@inproceedings{SmedSrensen2012InfluenzaAV,
  title={Influenza A Virus Infection of Human Primary Dendritic Cells Impairs Their Ability to Cross-Present Antigen to CD8 T Cells},
  author={Anna Smed-S{\"o}rensen and C{\'e}cile Chalouni and Bithi Chatterjee and Lillian E. Cohn and Peter Blattmann and Norihiro Nakamura and L{\'e}lia Delamarre and Ira Mellman},
  booktitle={PLoS pathogens},
  year={2012}
}
Influenza A virus (IAV) infection is normally controlled by adaptive immune responses initiated by dendritic cells (DCs). We investigated the consequences of IAV infection of human primary DCs on their ability to function as antigen-presenting cells. IAV was internalized by both myeloid DCs (mDCs) and plasmacytoid DCs but only mDCs supported viral replication. Although infected mDCs efficiently presented endogenous IAV antigens on MHC class II, this was not the case for presentation on MHC… CONTINUE READING