Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin

  title={Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin},
  author={Jie Yang and Minmin Li and Xintian Shen and Shuwen Liu},
Influenza A virus (IAV) has caused seasonal influenza epidemics and influenza pandemics, which resulted in serious threat to public health and socioeconomic impacts. Until now, only 5 drugs belong to two categories are used for prophylaxis and treatment of IAV infection. Hemagglutinin (HA), the envelope glycoprotein of IAV, plays a critical role in viral binding, fusion and entry. Therefore, HA is an attractive target for developing anti‑IAV drugs to block the entry step of IAV infection. Here… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 87 references

A cell-penetrating helical peptide as a potential HIV-1 inhibitor.

Journal of molecular biology • 2008
View 11 Excerpts
Highly Influenced

Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.

Annual review of biochemistry • 2000
View 3 Excerpts
Highly Influenced

Antivirals targeting influenza A virus.

Journal of medicinal chemistry • 2012
View 1 Excerpt

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