Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay.

@article{Ehrlenbach2009InfluencesOT,
  title={Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay.},
  author={Silvia Ehrlenbach and Peter Willeit and Stefan Kiechl and Johann Willeit and Markus Reindl and Kathrin Schanda and Florian Kronenberg and Anita Brandstaetter},
  journal={International journal of epidemiology},
  year={2009},
  volume={38 6},
  pages={1725-34}
}
BACKGROUND Telomeres play a key role in the maintenance of chromosome integrity. Short telomeres are linked to age-associated diseases and cancer. Our aim was to determine the decrease rate of relative telomere length (RTL) over 10 years and whether this rate was influenced by age, sex and smoking behaviour. METHODS We compared RTL in 510 sample pairs from the longitudinal population-based Bruneck Study, which were collected in 1995 and recollected in 2005, and additionally determined RTL… CONTINUE READING