Influences of the lysosomal associated membrane proteins (Lamp‐1, Lamp‐2) and Mac‐2 binding protein (Mac‐2‐BP) on the prognosis of pancreatic carcinoma

@article{Knzli2002InfluencesOT,
  title={Influences of the lysosomal associated membrane proteins (Lamp‐1, Lamp‐2) and Mac‐2 binding protein (Mac‐2‐BP) on the prognosis of pancreatic carcinoma},
  author={Beat K{\"u}nzli and Pascal O. Berberat and Zhaowhen W. Zhu and Marc Eric Martignoni and J{\"o}rg Kleeff and Adrien A. Tempia-Caliera and Minoru Fukuda and Arthur Zimmermann and Helmut Friess and Markus W. B{\"u}chler},
  journal={Cancer},
  year={2002},
  volume={94}
}
Lamps and Mac‐2‐BP are ligands of galectin‐3, and they were suggested to influence tumor proliferation and metastasis formation. The authors studied the expression of Lamp‐1, Lamp‐2, and Mac‐2‐BP in pancreatic carcinoma and evaluated their influence on patient prognosis. 
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LAMP1 expression is associated with poor prognosis in breast cancer
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The results suggested that LAMP1 expression is associated with malignant attributes of BC and may serve as a novel prognostic factor for patients with BC.
Transthyretin interacts with the lysosome-associated membrane protein (LAMP-1) in circulation.
TLDR
Only LAMP-1 (+Tail) was found to aggregate and interact with plasma proteins and Transthyretin exists as a homotetramer in plasma, as such may play a role in the aggregation of Lamp-1 in circulation.
Tumor‐associated antigen 90K/Mac‐2‐binding protein: Possible role in colon cancer
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A possible mechanism by which TAA90K may contribute to colon cancer progression is by modulating tumor cell adhesion to extracellular proteins, including galectin‐3.
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