Influences of non-selective interactions of nucleic acids on response rates of nucleic acid fiber optic biosensors.

The immobilization of oligonucleotides to solid surfaces can provide a platform of chemistry that is suitable for the development of biosensor and microarray technologies. Experiments were performed using a fiber optic nucleic acid biosensor based on total internal reflection fluorescence to examine the effects of the presence of non-complementary DNA on… CONTINUE READING