Influences of extracellular matrix and of conditioned media on differentiation and invasiveness of trophoblast stem cells.

@article{Lei2007InfluencesOE,
  title={Influences of extracellular matrix and of conditioned media on differentiation and invasiveness of trophoblast stem cells.},
  author={Ting Lei and H. P. Hohn and Ruediger Behr and H W Denker},
  journal={Placenta},
  year={2007},
  volume={28 1},
  pages={14-21}
}
Embryo implantation in the human and rodents relies on the trophoblast's ability to invade into the uterine stroma, partly depending on proteinases degrading components of basement membrane and underlying extracellular matrix (ECM). We have utilized mouse trophoblast stem (TS) cells (Science, 1998, 282:2072) to study trophoblast invasion and trophoblast-ECM interactions in vitro. On plastic in fibroblast-conditioned medium containing fibroblast growth factor (FGF)-4 and heparin, the cells… CONTINUE READING
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