Influences of cyclooxygenase-1 and -2 expression on the radiosensitivities of human cervical cancer cell lines.

@article{Jeon2007InfluencesOC,
  title={Influences of cyclooxygenase-1 and -2 expression on the radiosensitivities of human cervical cancer cell lines.},
  author={Yong-Tark Jeon and Yoo-Cheol Song and Su-Hyeong Kim and Hong-Gyun Wu and Il-Han Kim and In-ae Park and Jae Weon Kim and Noh-Hyun Park and S Kang and H Lee and Yong Sang Song},
  journal={Cancer letters},
  year={2007},
  volume={256 1},
  pages={33-8}
}
We utilized three cervical cancer cell lines (HeLa, HT-3, and C33A) and clonogenic assays to determine whether cyclooxygenase (COX) expression is related to radiosensitivity. Using COX DNA transfection and COX inhibition by siRNA, we also examined changes in radiosensitivity caused by variations in COX expression. The survival fractions of HeLa and HT-3 cell lines, which both with COX-1 and COX-2 activity, were found to be significantly higher than that of the C33A cell line which had neither… CONTINUE READING