Influences of chromosome size, gene density and nuclear position on the frequency of constitutional translocations in the human population

@article{Bickmore2002InfluencesOC,
  title={Influences of chromosome size, gene density and nuclear position on the frequency of constitutional translocations in the human population},
  author={Wendy A. Bickmore and Peter W. Teague},
  journal={Chromosome Research},
  year={2002},
  volume={10},
  pages={707-715}
}
Translocations are the most frequent chromosome structural aberration in the human population, yet little is known about their aetiology. Here, factors that might influence the occurrence of constitutional translocations in the population are examined. By analysing >10 000 translocations from two large databases of cytogenetic abnormalities, chromosome size is identified as the major determinant of translocation frequency. This probably reflects the large target size for double-strand breakage… CONTINUE READING
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The sequence of the human genome

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Highly Influential
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