Influences of array size and homogeneity on minisatellite mutation.

  title={Influences of array size and homogeneity on minisatellite mutation.},
  author={Jerome Buard and Agn{\`e}s Bourdet and Jill Yardley and Yuri E. Dubrova and Alec John Jeffreys},
  journal={The EMBO journal},
  volume={17 12},
Unstable minisatellites display high frequencies of spontaneous gain and loss of repeats in the human germline. Most length changes arise through complex recombination events including intra-allelic duplications/deletions and inter-allelic transfers of repeats. Definition of the factors modulating instability requires both measurement of mutation rate and detailed analysis of mutant structures at the level of individual alleles. We have measured mutation rates in sperm for a wide range of… CONTINUE READING


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