Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice.

@article{Desai1996InfluencesOA,
  title={Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice.},
  author={Varsha G. Desai and Richard Weindruch and Ronald W. Hart and Ritchie J. Feuers},
  journal={Archives of biochemistry and biophysics},
  year={1996},
  volume={333 1},
  pages={145-51}
}
Alterations in the mitochondrial electron transport system (ETS) may contribute to aging. Dietary restriction (DR) provides a model to investigate retarded aging. ETS activities were measured in gastrocnemius from 10- and 20-month-old B6C3F1 female mice fed either ad libitum (AL) or DR diets (40% < AL). Older (26 month old) AL mice were studied for complex IV. Activities of complexes I, III, and IV decreased 54-74% from 10 to 20 months of age in AL mice. At 10 months, activities of complexes I… CONTINUE READING