Influences of aflatoxin B1 on reactive oxygen species generation and chemotaxis of human polymorphonuclear leukocytes.

@article{Ubagai2008InfluencesOA,
  title={Influences of aflatoxin B1 on reactive oxygen species generation and chemotaxis of human polymorphonuclear leukocytes.},
  author={Tsuneyuki Ubagai and Shigeru Tansho and Tadashi Ito and Yasuo Ono},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2008},
  volume={22 4},
  pages={1115-20}
}
The effects of aflatoxin (AF), a hepatotoxic agent and the strongest carcinogen in nature, on polymorphonuclear leukocyte (PMN) chemotaxis and chemiluminescence (CL) were studied. Luminol-dependent CL activity, which reflects the production of reactive oxygen species (ROS) from PMNs, was up-regulated to approximately 150% when PMNs were treated with 0.05 ng/ml of AFB1 upon stimulation with N-formyl-methionine-leucine-phenylalanine (fMLP) or zymosan. On the other hand, PMN CL activity was down… CONTINUE READING
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