Influences of Chloride and Hypochlorite on Neutrophil Extracellular Trap Formation

  title={Influences of Chloride and Hypochlorite on Neutrophil Extracellular Trap Formation},
  author={Kathryn Akong-Moore and Ohn A. Chow and Maren von K{\"o}ckritz-Blickwede and Victor Nizet},
  booktitle={PloS one},
BACKGROUND The release by neutrophils of DNA-based extracellular traps (NETs) is a recently recognized innate immune phenomenon that contributes significantly to control of bacterial pathogens at tissue foci of infection. NETs have also been implicated in the pathogenesis of non-infectious diseases such as small vessel vasculitis, lupus and cystic fibrosis lung disease. Reactive oxygen species (ROS) are important mediators of NET generation (NETosis). Neutrophils with reduced ROS production… CONTINUE READING


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