Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study.

@article{Wilkinson2000InfluenceOV,
  title={Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study.},
  author={Robert J Wilkinson and Megan Llewelyn and Zahra Toossi and Purushottam Patel and Geoffrey Pasvol and Ajit Lalvani and David Wright and M Farooq Latif and Robert N. Davidson},
  journal={Lancet},
  year={2000},
  volume={355 9204},
  pages={618-21}
}
BACKGROUND Susceptibility to disease after infection by Mycobacterium tuberculosis is influenced by environmental and host genetic factors. Vitamin D metabolism leads to activation of macrophages and restricts the intracellular growth of M. tuberculosis. This effect may be influenced by polymorphisms at three sites in the vitamin D receptor (VDR) gene. We… CONTINUE READING